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Ovagen

● Research (Khavinson Institute)
Ovagen, Hepatic & Liver Bioregulator (Glu-Asp-Glu)
Also known as: Khavinson peptide liver, liver bioregulator, hepatic tripeptide
Brand names: Ovagen (Peptides by Khavinson)
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Quick Summary

Ovagen is a tripeptide bioregulator (Glu-Asp-Glu) developed by the St. Petersburg Institute of Bioregulation and Gerontology (Khavinson team).

Organ Support Research Use (CIS)
Ovagen is a tripeptide bioregulator (Glu-Asp-Glu) developed by the St. Petersburg Institute of Bioregulation and Gerontology (Khavinson team). It is targeted to hepatocyte support and liver function improvement. Bioregulators in the Khavinson system are short peptides that act as gene expression switches, binding to specific promoter regions of target tissue DNA and normalizing protein synthesis. The 16-week oral cycle is characteristic of this peptide family.
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Storage Stability
Lyophilized
6–12 months (2–8°C)
Reconstituted
N/A (oral)
Room temp
Stable (capsule)

Mechanism of Action

Epigenetic Gene Regulation

Khavinson's bioregulator peptides are proposed to enter cells and interact with specific DNA promoter sequences, acting as transcription-activating factors for target tissue-specific genes. For hepatic cells, Ovagen is proposed to normalize expression of liver detoxification and structural proteins.

Hepatocyte Protein Synthesis

Research from the Khavinson Institute shows tripeptide bioregulators increase target-tissue protein synthesis within 2–4 weeks of treatment in aged cell cultures and animal models.

Antioxidant Support

Glutamate and aspartate residues participate in glutathione precursor pathways; the peptide may support hepatic GSH levels indirectly.

Research Summary

Khavinson Institute Studies

Russian studies report improvements in hepatic enzyme profiles (ALT, AST normalization) and liver histology in models of liver damage treated with Ovagen-family peptides.

Longevity Data

Part of the broader Khavinson bioregulator longevity program showing ~20–40% lifespan extension in rodent models with multi-bioregulator protocols.
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Research Protocols

Oral Cycle

10–30 mg/day orally for 16 weeks. This is the Khavinson standard cycle for bioregulators. Two cycles per year is common in Russian literature.

SubQ Protocol

1–2 mg daily subcutaneously for 10–20 days (shorter courses used in clinical settings in Russia).

Storage & Handling

Store at 2–8°C. Freeze lyophilized" class="wiki-gloss-link">lyophilized for long-term. Reconstitute with sterile or bacteriostatic water for SubQ use. Oral tablets store at room temperature per manufacturer.

References

  • [1]Khavinson VKh, et al. "Short peptides stimulate cell viability and protein synthesis in hepatic tissue." Biogerontology, 2013.
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See Also

epithalonthymalinvesugenvilonlivagen
Categories: Organ SupportBioregulatorLiverLongevityKhavinson
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Verified Scientific Data Last audited:
Data Sources & External References
⬡ PubMed / NCBI, Research Literature ⬡ NCBI, Full-Text Articles ⬡ PubChem, Chemical Database
Source: peer-reviewed literature  ·  Domain: ascendpeptide.org
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