Antimicrobial & Immune

Thymosin Alpha-1 (TA1) is a 28-amino acid peptide naturally secreted by thymic epithelial …

LL-37 is the only human cathelicidin, the C-terminal 37-amino acid fragment of the precur…

Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide expressed throughout t…

Thymopentin, also known as TP-5, is a synthetic pentapeptide corresponding to amino acids …

Bombesin is a 14-amino acid neuropeptide originally isolated from the skin of the European…

Resistin is a 12.5 kDa cysteine-rich adipokine identified in 2001 as an adipose-derived fa…

Chemerin is a 16 kDa multifunctional protein secreted primarily by adipose tissue, liver, …

Histatin-5 is a 24-amino acid histidine-rich peptide secreted by the parotid and submandib…

Motixafortide (Aphexda) is a cyclic peptide CXCR4 antagonist FDA-approved in 2023 in combi…

Hepcidin is a 25-amino acid antimicrobial peptide that serves as the master regulator of s…

Magainins are cationic, alpha-helical antimicrobial peptides (AMPs) isolated from the skin…

Defensins are a superfamily of small, cysteine-rich cationic antimicrobial peptides that f…

Temporins are a family of short (10-14 amino acid) cationic antimicrobial peptides isolate…

LL-37 is the sole human cathelicidin antimicrobial peptide, derived by proteolytic cleavag…

Dermaseptins are a family of 28-34 amino acid antimicrobial peptides first isolated from t…

Buforin II is a 21-residue antimicrobial peptide derived from histone H2A in the stomach o…

Protegrins are disulfide-bridged beta-hairpin antimicrobial peptides isolated from porcine…

Tachyplesin I is an 18-residue disulfide-bridged beta-hairpin AMP from the hemocytes of th…

Indolicidin is a 13-residue, tryptophan-rich antimicrobial peptide from bovine neutrophil …

Vasohibin-1 (VASH1) is an endogenous angiogenesis inhibitor secreted by endothelial cells …

Brevinin peptides are a family of antimicrobial peptides isolated from the skin secretions…

Esculentins are the longest known naturally occurring antimicrobial peptides, isolated fro…

Aurein peptides are a large family of short (13-25 residue) antimicrobial and anticancer p…

Caerins are a family of antimicrobial peptides from the Australian Blue Mountains tree fro…

Polyphemusin I is an antimicrobial peptide from the hemocytes of the American horseshoe cr…

PR-39 is a 39-residue proline- and arginine-rich antimicrobial peptide from porcine neutro…

Bactenecins are a diverse family of antimicrobial peptides from bovine neutrophil granules…

Tigerinin peptides are isolated from the skin of the Indian skipper frog Hoplobatrachus ti…

Cecropins are a family of antimicrobial peptides first discovered in 1980 by Hans Boman in…

Apidaecins are proline-rich antimicrobial peptides from the hemolymph of honeybees (Apis m…

Drosocin is a 19-residue O-glycosylated proline-rich antimicrobial peptide from Drosophila…

PGLa is a 22-residue alpha-helical antimicrobial peptide co-isolated with magainin-2 from …

Phylloseptins are a family of short, C-terminally amidated alpha-helical antimicrobial pep…

Maximins are a large and diverse family of antimicrobial and neuroactive peptides isolated…

Kalata B1 is the prototype cyclotide, a cyclic peptide with a head-to-tail backbone cycli…

ShK is a 35-residue peptide toxin from the sea anemone Stichodactyla helianthus. It is the…

Lactoferricin B (LfcinB) is a 25-residue antimicrobial peptide released from the N-termina…

Plectasin is a 40-residue defensin-like antimicrobial peptide discovered in 2005 from the …

Nisin A is a 34-residue lanthipeptide bacteriocin produced by Lactococcus lactis. It is th…

Enfuvirtide (T-20, Fuzeon) is a 36-residue synthetic peptide derived from the C-terminal h…

Pexiganan (MSI-78) is a synthetic analog of magainin-2, optimized for enhanced broad-spect…

Omiganan (CLS001, MBI-226) is a synthetic analog of indolicidin, a bovine neutrophil AMP. …

Human Neutrophil Peptide 1 (HNP-1) is the most abundant alpha-defensin in human neutrophil…

Human beta-defensin 2 (HBD-2) is an inducible antimicrobial peptide expressed by skin kera…

Albuvirtide is a long-acting HIV-1 fusion inhibitor approved in China in 2018. It is deriv…

Tyrocidine A is a cyclic decapeptide component of tyrothricin, one of the first antibiotic…

Ramoplanin is a glycodepsipeptide antibiotic produced by Actinoplanes sp. ATCC 33076 with …

ALRN-6924 (sulanemadlin) is a hydrocarbon-stapled alpha-helical peptide developed by Ailer…

Arenicin is a beta-hairpin antimicrobial peptide isolated from the coelomocytes of the lug…

Clavanin is a histidine-rich alpha-helical antimicrobial peptide originally isolated from …

Ponericins are a family of antimicrobial peptides isolated from the venom of the ant Pachy…

Pyrrhocoricin is a proline-rich antimicrobial peptide from the hemipteran insect Pyrrhocor…

Dermcidin is a constitutively expressed antimicrobial peptide produced by eccrine sweat gl…

Human beta-defensin-1 (HBD-1) is a constitutively expressed antimicrobial peptide produced…

Theta-defensins are the only known cyclic peptides produced in the animal kingdom. Found i…

Gramicidin S (Soviet gramicidin) is a cyclic decapeptide antibiotic discovered in 1942 by …

Gramicidin A is a 15-residue linear peptide antibiotic from Bacillus brevis, distinct from…

Polymyxin B is a cyclic lipopeptide antibiotic from Bacillus polymyxa that was approved in…

Colistin (polymyxin E) is a cyclic lipopeptide antibiotic structurally related to polymyxi…

Bacitracin is a polycyclic peptide antibiotic from Bacillus subtilis licheniformis, first …

Teixobactin was reported in Nature in 2015 as the first new antibiotic class discovered in…

Daptomycin (Cubicin) is a cyclic lipopeptide antibiotic from Streptomyces roseosporus, FDA…

Alamethicin is a 20-residue peptaibol (peptide with a high proportion of alpha-aminoisobut…

Protegrin-1 (PG-1) is an 18-residue cationic beta-hairpin antimicrobial peptide isolated f…

Decorin is a small leucine-rich proteoglycan (SLRP) with a ~36 kDa protein core decorated …

Endorepellin is the C-terminal domain V of the large heparan sulfate proteoglycan perlecan…

Canstatin is the non-collagenous domain-1 (NC1) of the collagen IV alpha-2 chain, generate…

Vasohibin-1 (VASH1) is an endogenous angiogenesis inhibitor secreted by vascular endotheli…

Vasohibin-2 (VASH2) is a paralog of vasohibin-1 with opposing function: it promotes angiog…

Endostatin is a 20 kDa C-terminal fragment of collagen XVIII generated by proteolytic clea…

Tumstatin is the non-collagenous domain-1 (NC1) of the collagen IV alpha-3 chain (Col4a3),…

Angiostatin is a proteolytic fragment of plasminogen comprising kringle domains 1 through …

Lumican is a keratan sulfate-bearing small leucine-rich proteoglycan (SLRP) critical for c…

PNC-27 is a synthetic peptide containing the p53 HDM2-binding domain linked to a transmemb…