Storage Stability
Mechanism of Action
GLP-1 Component
GLP-1 receptor activation reduces appetite, slows gastric emptying, stimulates glucose-dependent insulin secretion, and suppresses glucagon from pancreatic alpha cells.Glucagon Component
Glucagon receptor activation increases hepatic glucose output (managed by co-existing GLP-1 suppression), promotes lipolysis in adipose tissue, and increases resting energy expenditure through thermogenesis, mechanisms that amplify fat loss beyond GLP-1 alone.Dual Receptor Balance
The key design challenge of dual agonists: glucagon's hyperglycemic effects are offset by simultaneous GLP-1 receptor activation. The 1:1 or weighted balance in the molecule determines net glycemic impact.Research Summary
Phase III GLORY Trial (China)
In 568 obese Chinese adults, mazdutide 6 mg and 9 mg weekly for 36 weeks produced 14.4% and 15.8% body weight loss respectively, vs. 2.0% with placebo. Significant improvements in metabolic markers including waist circumference, blood pressure, and lipids.T2DM Sub-Group
In patients with type 2 diabetes, mazdutide reduced HbA1c by 1.7% with the 6 mg dose.vs. Western Competitors
Mazdutide's weight loss (~15–17%) sits between semaglutide (~15%) and tirzepatide (~20–22%). Its differentiation is the glucagon receptor activity which may offer metabolic advantages in NAFLD/MASH.Calculate your Mazdutide dose Vial strength, BAC water, exact syringe draw in IU. Free, no signup. Open Calc →
Research Protocols
Titration
Start at 3 mg weekly for 4 weeks, increase to 6 mg for 4 weeks, then 9 mg maintenance if tolerated. GI side effects peak during titration.Injection
Subcutaneous injection once weekly. Abdomen, thigh, or upper arm. Rotate sites.Storage & Handling
Refrigerate at 2–8°C. Do not freeze. Protect from light. Can be kept at room temperature (<30°C) for limited period per manufacturer guidance.
References
- [1]Ji L, et al. "Mazdutide for obesity in Chinese adults (GLORY): Phase 3 RCT." Nat Med, 2024.
- [2]Lv W, et al. "IBI362, a GLP-1/glucagon receptor dual agonist, for T2DM and obesity." J Diabetes, 2023.
Ready to dose Mazdutide?
Get the exact syringe draw
You have read the research. Now run the math. Pick your vial size and BAC water volume, get IU draw in seconds.
Open the Calculator →
More in Weight Loss & Metabolic
View all →