Storage Stability
Mechanism of Action
Adipotide is a bipartite peptide with two functional domains joined by a GG linker.
Homing Domain: CKGGRAKDC
This sequence binds prohibitin, a protein highly expressed on the luminal surface of blood vessels feeding white adipose tissue. Prohibitin serves as the address label that delivers the peptide specifically to fat vasculature.Apoptotic Domain: D(KLAKLAK)2
Once homed to adipose vasculature, the D(KLAKLAK)2 sequence inserts into mitochondrial membranes of vascular endothelial cells, disrupting membrane potential and triggering apoptosis.Selective Fat Loss
As adipose vasculature is destroyed, the surrounding fat cells lose blood supply and undergo ischemic apoptosis. Lean tissue vasculature does not express prohibitin at the same density, providing selectivity.Research Summary
Primate Study (2011)
The landmark NCI-funded study in obese rhesus monkeys showed 39% reduction in visceral fat and 27% reduction in subcutaneous fat over 28 days at 1 mg/kg/day. BMI dropped significantly. Lean mass was preserved.Nephrotoxicity
All animals showed kidney damage at the research dose, with elevated creatinine and BUN. Kidney function recovered partially after cessation, but this is the primary barrier to clinical development.Dose-Finding
No dose has been identified that separates fat loss efficacy from renal toxicity. This remains an active research problem.Calculate your Adipotide dose Vial strength, BAC water, exact syringe draw in IU. Free, no signup. Open Calc →
Research Protocols
Note: Adipotide carries significant nephrotoxicity risk at doses that produce fat loss in primates. Kidney function monitoring (creatinine, BUN) is essential in any research context.
Research Dose
NCI primate protocols used 1 mg/kg subcutaneously daily for 28 days. Lower doses (0.1–0.5 mg/kg) have been explored but efficacy data is limited.Hydration
High fluid intake is critical during research protocols to reduce renal stress.Storage & Handling
Store lyophilized" class="wiki-gloss-link">lyophilized powder at -20°C. Reconstitute with sterile water. Use reconstituted solution within 7 days when stored at 2–8°C. Protect from freeze-thaw cycles after reconstitution.
References
- [1]Barnhart KF, et al. "A peptidomimetic targeting white fat causes weight loss." Science Translational Medicine, 2011.
- [2]Kolonin MG, et al. "Reversal of obesity by targeted ablation of adipose tissue." Nature Medicine, 2004.
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