Storage Stability
Mechanism of Action
Adamax (N-Acetyl Semax Amidate) acts primarily through BDNF (Brain-Derived Neurotrophic Factor) upregulation, alpha-msh/" class="wiki-internal-link">melanocortin receptor modulation, and cholinergic system support.
BDNF Upregulation
N-Acetyl Semax Amidate has been shown to dramatically increase BDNF expression in the prefrontal cortex and hippocampus, regions central to working memory and executive function. BDNF supports neuronal survival, synaptic plasticity, and long-term potentiation.Melanocortin Receptors
As an acth/" class="wiki-internal-link">ACTH(4-7) analog, Adamax activates MC4R in the brain, influencing dopamine and serotonin turnover, which improves motivation, attention, and stress resilience.Cholinergic Enhancement
Research suggests Semax analogs enhance acetylcholine synthesis and release in the hippocampus, improving short-term memory encoding.Research Summary
Russian Clinical Data
Semax (the parent compound) has been approved and used clinically in Russia since 1997 for ischemic stroke, optic nerve disease, and cognitive disorders. N-Acetyl Semax Amidate is the research evolution of this compound with enhanced potency.Cognitive Performance
Human and animal studies on Semax analogs show improvements in attention span, working memory, and learning rate. N-Acetyl modification approximately doubles potency relative to standard Semax.Neuroprotection
Animal stroke models show reduced infarct size and faster neurological recovery with Semax treatment, attributed to anti-inflammatory effects and BDNF-mediated neurogenesis.Calculate your Adamax dose Vial strength, BAC water, exact syringe draw in IU. Free, no signup. Open Calc →
Research Protocols
Dosing
Typical research dose is 100–300 µg intranasally. Some protocols go up to 600 µg but higher doses show diminishing returns on cognition.Administration
Administer as nasal drops (not spray), tilt head back, apply drops, then tilt head forward to allow absorption through nasal mucosa. Each nostril absorbs independently.Cycle
2–4 week cycles are common in research protocols. Some researchers use daily for 2 weeks then take 2 weeks off. Effects on BDNF may persist beyond the dosing period.Storage & Handling
Adamax is supplied as a lyophilized" class="wiki-gloss-link">lyophilized powder. Reconstitute with sterile water or bacteriostatic water. Store reconstituted solution at 2–8°C and use within 30 days. Keep lyophilized powder frozen for long-term storage. Protect from light.
References
- [1]Manchenko DM, et al. "Semax and its analogs: BDNF-mimetic effects." Neuroscience & Behavioral Physiology, 2012.
- [2]Eremin KO, et al. "Semax affects the brain dopaminergic and serotonergic systems." Bulletin of Experimental Biology and Medicine, 2005.
Ready to dose Adamax?
Get the exact syringe draw
You have read the research. Now run the math. Pick your vial size and BAC water volume, get IU draw in seconds.
Open the Calculator →
More in Cognitive & Mood
View all →