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N-Acetyl Semax

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N-Acetyl Semax, Acetylated Semax Variant
Also known as: NA Semax, Acetyl Semax, N-Acetyl Semax (non-amidate)
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Quick Summary

N-Acetyl Semax is a modified form of Semax (the Russian-approved nootropic peptide based on ACTH(4-7)) with N-terminal acetylation added for improved enzymatic stability. The acetyl group protects against aminopeptidase degradation in nasal tissue, extending effective half-life and improving CNS penetration versus standard Semax.

Cognitive & Neurological Research Use
N-Acetyl Semax is a modified form of Semax (the Russian-approved nootropic peptide based on acth/" class="wiki-internal-link">ACTH(4-7)) with N-terminal acetylation added for improved enzymatic stability. The acetyl group protects against aminopeptidase degradation in nasal tissue, extending effective half-life and improving CNS penetration versus standard Semax. It is a step between standard Semax and the fully-modified N-Acetyl Semax Amidate (Adamax). Primary uses are cognitive enhancement, BDNF upregulation, and neuroprotection.
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Storage Stability
Lyophilized
6–12 months (2–8°C)
Reconstituted
~30 days (2–8°C)
Room temp
Avoid

Mechanism of Action

ACTH(4-7) Core

The Met-Glu-His-Phe core sequence activates alpha-msh/" class="wiki-internal-link">melanocortin receptors (MC4R predominantly) in the CNS, influencing dopamine and serotonin turnover and improving attention and cognitive flexibility.

BDNF Upregulation

Semax and N-Acetyl Semax increase BDNF expression in the hippocampus and prefrontal cortex, supporting long-term potentiation and memory consolidation.

N-Acetylation Effect

The acetyl group blocks N-terminal aminopeptidase cleavage, which is the primary degradation pathway for Semax in nasal tissue. This extends the peptide's residence time in the olfactory mucosa and increases CNS delivery versus unmodified Semax.

Research Protocols

Dosing

100–400 µg intranasally. Higher doses than standard Semax may be used due to improved stability. Some protocols use 300–600 µg daily.

Comparison to Adamax

N-Acetyl Semax is less potent than N-Acetyl Semax Amidate (Adamax) because it lacks C-terminal amidation. Adamax is the highest-potency form; N-Acetyl Semax is intermediate between standard Semax and Adamax.
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Storage & Handling

Refrigerate at 2–8°C. Freeze lyophilized" class="wiki-gloss-link">lyophilized for long-term. Reconstitute with sterile water. Use within 30 days. Protect from light.

References

  • [1]Manchenko DM, et al. "Comparative study of Semax and N-Acetyl Semax BDNF effects." Neuroscience, 2012.
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See Also

semaxadamaxselankn-acetyl-selank-amidatedihexa
Categories: CognitiveNootropicBDNFIntranasalSemax Analog
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Verified Scientific Data Last audited:
Data Sources & External References
⬡ PubMed / NCBI, Research Literature ⬡ NCBI, Full-Text Articles ⬡ PubChem, Chemical Database
Source: peer-reviewed literature  ·  Domain: ascendpeptide.org
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