FDA-APPROVED

Anastrozole (Arimidex)Active: Anastrozole

Quick reference: Off-label TRT use: 0.25 to 1 mg orally twice weekly, titrated to sensitive E2 in the 20 to 30 pg/mL range. Crushing low E2 is harmful.

Fast facts

Active
Anastrozole
Maker
AstraZeneca (originator) and generics
FDA Approval
1995
Half-life
~50 hours
Form
Oral tablet, 1 mg. Compounded liquid suspensions also available.
Indication
FDA-approved for hormone-receptor-positive breast cancer in postmenopausal women. Off-label use in male TRT protocols when symptomatic estradiol elevation occurs.

Dose schedule

Off-label TRT use: 0.25 to 1 mg orally twice weekly, titrated to sensitive E2 in the 20 to 30 pg/mL range. Crushing low E2 is harmful.

Recommended monitoring

Sensitive E2 every 6 weeks until stable; symptoms (mood, libido, joint comfort).

Clinical notes

Routine AI use during TRT is controversial. Many endocrinologists reserve it for documented symptomatic E2 elevation, not preventive use.

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Frequently asked

What is the typical dose schedule for Anastrozole (Arimidex)?
Off-label TRT use: 0.25 to 1 mg orally twice weekly, titrated to sensitive E2 in the 20 to 30 pg/mL range. Crushing low E2 is harmful.
What is the half-life of Anastrozole?
Anastrozole (Arimidex) has a half-life of approximately ~50 hours.
What monitoring labs are recommended on Anastrozole (Arimidex)?
Sensitive E2 every 6 weeks until stable; symptoms (mood, libido, joint comfort).
Is Anastrozole (Arimidex) the same as compounded anastrozole?
Anastrozole (Arimidex) is a finished FDA-approved drug product with consistent quality control. Compounded anastrozole produced by 503A or 503B pharmacies contains the same active ester but is not held to identical manufacturing standards. Verify the Certificate of Analysis when using a compound.
Is Anastrozole (Arimidex) a controlled substance?
Anastrozole (Arimidex) is not a controlled substance in the United States. A standard prescription is required for clinical use.

Related

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For research informational use only. Not medical advice. Anastrozole (Arimidex) is a registered trademark of AstraZeneca (originator) and generics. Consult a qualified healthcare provider before any clinical decision. ASCEND, ascendpeptide.org

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