SKIN & HAIR STACK
Melanotan II + PT-141Pigmentation + libido (melanocortin axis)
Synergy: Melanotan II is a non-selective melanocortin agonist driving melanogenesis and libido effects via MC1R + MC4R; PT-141 (Bremelanotide) is more MC4R-selective and FDA-approved for hypoactive sexual desire disorder. Some users layer for both tanning and sexual function effects.
Stack components
Melanotan II
Cosmetic
Non-selective melanocortin agonist for tanning, libido, and appetite suppression.
250 µg draw on 100u syringe
PT-141
Sexual Health
Melanocortin receptor agonist (Bremelanotide) for sexual dysfunction. FDA-approved Vyleesi dose: 1.75 mg SQ.
1.75 mg draw on 100u syringe
Injection timing
Melanotan II: SC during loading phase then maintenance. PT-141: SC or intranasal as needed.
Same syringe or separate?
Separate doses, different cadences.
Typical cycle length
Melanotan II: loading then maintenance. PT-141: as-needed.
Research use only. Peptide stacks compound effects and side-effect risk. Always verify Certificates of Analysis for each peptide. Consult a qualified clinician before initiating any combined protocol.
Open the calculators
Frequently asked
What does the Melanotan II + PT-141 stack do?
Melanotan II is a non-selective melanocortin agonist driving melanogenesis and libido effects via MC1R + MC4R; PT-141 (Bremelanotide) is more MC4R-selective and FDA-approved for hypoactive sexual desire disorder. Some users layer for both tanning and sexual function effects.
When should Melanotan II and PT-141 be injected?
Melanotan II: SC during loading phase then maintenance. PT-141: SC or intranasal as needed.
Can Melanotan II and PT-141 be drawn into the same syringe?
Separate doses, different cadences.
How long is a typical Melanotan II + PT-141 cycle?
Melanotan II: loading then maintenance. PT-141: as-needed.
What dose of Melanotan II pairs with PT-141?
Standard ASCEND reference dose for Melanotan II: 250 µg from a 10 mg vial reconstituted with 2 mL bacteriostatic water (5000 µg/mL). Draw volume at this concentration: 0.05 mL, which is 5 IU on a 100-unit insulin syringe. Adjust to the research protocol you are following.
Related
For research informational use only. Not medical advice. Combination protocols have not been formally validated by the FDA. Consult a qualified healthcare provider before initiating any peptide stack.