Storage Stability
Mechanism of Action
MC1R, Tanning
Activation of MC1R on melanocytes stimulates eumelanin production (dark/brown pigment) and transfer to keratinocytes, producing a tan without UV exposure. Also provides photoprotection by increasing melanin density.MC4R, Libido & Appetite
Hypothalamic MC4R activation increases dopamine in the mesolimbic system, driving arousal and sexual motivation. The same MC4R pathway reduces food intake, accounting for appetite suppression side effects.MC3R, Autonomic Effects
MC3R activation contributes to the cardiovascular and autonomic effects (flushing, yawning) often reported at higher doses.Non-Selectivity Trade-off
MT-II's lack of receptor selectivity gives it broader effects than targeted agents but also more side effects (nausea, spontaneous erections, flushing).Research Summary
Tanning Efficacy
Multiple studies confirm MT-II produces significant melanin increase (objective colorimetry measurement) within 2–4 weeks of daily dosing, requiring minimal or no UV exposure to achieve tan.Sexual Function
In men with erectile dysfunction, MT-II produced clinically relevant erections in 80% of subjects in small crossover trials, the data that drove PT-141 development (which removes the tanning effect via its hydroxylated structure).Appetite Suppression
Animal studies show potent anorexic effects; human reports consistently describe appetite suppression particularly in the first weeks of use.Calculate your Melanotan II dose Vial strength, BAC water, exact syringe draw in IU. Free, no signup. Open Calc →
Research Protocols
Tanning Protocol
Start at 100–250 µg SubQ to assess tolerance. Progress to 500 µg daily until desired pigmentation achieved, then 2–3x/week maintenance. UV exposure (even brief) amplifies tanning response.Side Effect Management
Nausea is the most common adverse effect, dose in the evening to sleep through peak nausea window. Yawning, flushing, and spontaneous erections are common at 500 µg+.Storage & Handling
Store lyophilized" class="wiki-gloss-link">lyophilized at -20°C long-term. Reconstitute with bacteriostatic water. Refrigerate reconstituted solution at 2–8°C; use within 30 days. Protect from light.
References
- [1]Dorr RT, et al. "Evaluation of Melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase I clinical study." Life Sci, 1996.
- [2]Wessells H, et al. "MT-II-induced penile erections in men with psychogenic erectile dysfunction." J Urol, 1998.
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