Storage Stability
Mechanism of Action
Ghrelin Receptor Agonism (GHS-R1a)
MK-677 binds the ghrelin/" class="wiki-internal-link">ghrelin receptor (GHS-R1a) on pituitary somatotrophs, mimicking endogenous ghrelin's GH-releasing action. This stimulates GH synthesis and pulsatile secretion.Sustained IGF-1 Elevation
Due to its 24-hour half-life, MK-677 produces sustained GH elevation that drives continuous IGF-1 production in the liver, the primary anabolic mediator.Somatostatin Independence
GHS-R1a agonism partially bypasses somatostatin feedback that limits endogenous GH pulsatility, producing higher GH area-under-the-curve than natural secretion.Research Summary
Phase II, Muscle Wasting
In cachexia/muscle wasting patients, MK-677 25 mg/day for 8 weeks significantly increased lean mass (~2.7 kg) and GH/IGF-1 levels. Effect persisted for duration of treatment.Elderly Frailty
In adults 60–81 years old, MK-677 25 mg/day for 24 months increased muscle mass and strength and reduced falls frequency, without increasing fractures or cardiovascular events.GH Deficiency
Children with GHD showed increased growth velocity with MK-677, comparable to injectable GH, demonstrating the pituitary's preserved capacity when properly stimulated.Side Effects
Water retention, increased appetite, and transient insulin resistance at higher doses. Cortisol and prolactin may mildly increase.Calculate your MK-677 dose Vial strength, BAC water, exact syringe draw in IU. Free, no signup. Open Calc →
Research Protocols
Dosing
10–25 mg orally once daily. Most research protocols use 25 mg. Taking before bed reduces the GH pulse during sleep (natural peak amplification).Cycle
8–12 weeks. Some researchers use longer term; insulin sensitivity monitoring recommended for extended use.Water Retention Management
Moderate sodium restriction reduces the edema/water retention common in the first 2–4 weeks, which resolves with continued use.Storage & Handling
MK-677 is typically supplied as capsules or tablets (non-peptide). Store at room temperature, dry, away from light and moisture. Shelf life 2–3 years properly stored.
References
- [1]Copinschi G, et al. "MK-677 administered orally stimulates GH secretion." J Clin Endocrinol Metab, 1996.
- [2]Chapman IM, et al. "Stimulation of the GH/IGF-1 axis by daily oral MK-677 in elderly adults." J Clin Endocrinol Metab, 1996.
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