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CJC-1295 with DAC

○ Phase I (ConjuChem / historical)
CJC-1295 with Drug Affinity Complex (Maleimidoproprionic Acid)
Also known as: CJC-1295 DAC, CJC-1295 (with DAC), DAC-GRF
Brand names: CJC-1295 DAC (research grade)
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Quick Summary

CJC-1295 with DAC is a long-acting GHRH analog that uses a Drug Affinity Complex (DAC) technology, a reactive maleimidoproprionic acid linker that covalently bonds to plasma albumin after injection. This albumin binding dramatically extends its half-life to 6-8 days, allowing once or twice-weekly dosing.

Growth Hormone & IGF Research Use WADA Prohibited
CJC-1295 with DAC is a long-acting GHRH analog that uses a Drug Affinity Complex (DAC) technology, a reactive maleimidoproprionic acid linker that covalently bonds to plasma albumin after injection. This albumin binding dramatically extends its half-life to 6–8 days, allowing once or twice-weekly dosing. Unlike Mod GRF (No-DAC), CJC-1295 DAC produces sustained GH elevation rather than pulsatile spikes, which results in a different physiological profile and is less preferred by researchers who want to maintain natural GH rhythms.
Peptide calculator
Storage Stability
Lyophilized
1–2 years (-20°C)
Reconstituted
~30 days (2–8°C)
Room temp
Avoid

Mechanism of Action

Albumin Binding (DAC Technology)

The maleimidoproprionic acid (MPA) group on CJC-1295 DAC reacts with a free cysteine residue on circulating albumin at the injection site. This covalent bond turns the peptide into an albumin-bound depot, releasing gradually over 6–8 days as albumin is catabolized.

Sustained GHRH Receptor Activation

Continuous low-level GHRH receptor stimulation results in sustained GH elevation rather than the pulsatile spikes of Mod GRF. IGF-1 levels rise steadily over several days.

GH Bleed vs. Pulsatile

The "GH bleed" from CJC-1295 DAC mimics the GHRH infusion pattern. Researchers debate whether this sustained pattern is preferable to pulsatile for anabolism; most evidence suggests pulsatile is more physiological.

Research Summary

Phase I Clinical Trial

ConjuChem's Phase I trial showed a single injection of CJC-1295 DAC produced GH elevation lasting 6–8 days and sustained IGF-1 elevation for up to 14 days. The pharmacokinetic profile was consistent across subjects.

Anabolic Effects

Subjects showed improved nitrogen retention and lean mass trends over 4-week observation periods, consistent with elevated IGF-1.

Comparison to Mod GRF

For research purposes, most protocols now favor Mod GRF (No-DAC) + GHRP stacks for their pulsatile profile. CJC-1295 DAC is used when dosing convenience (once-weekly) is prioritized.
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Research Protocols

Weekly Protocol

1,000–2,000 µg once weekly SubQ. Can be combined with Ipamorelin for synergistic GH release on dosing days.

Twice Weekly

500–1,000 µg twice weekly maintains more stable IGF-1 levels.

Note on GHRP Stacking

Unlike Mod GRF, the sustained nature of CJC-1295 DAC limits the benefit of timing GHRP co-injection. GHRP can still be used independently on separate dosing schedules.

Storage & Handling

Keep lyophilized" class="wiki-gloss-link">lyophilized at -20°C. Reconstitute with bacteriostatic water. Refrigerate reconstituted solution at 2–8°C. Due to the reactive MPA group, CJC-1295 DAC is more sensitive to temperature fluctuations than Mod GRF, avoid leaving at room temperature.

References

  • [1]Alba M, et al. "Once-daily administration of CJC-1295, a long-acting GHRH analog." J Clin Endocrinol Metab, 2006.
  • [2]Jetté L, et al. "hGH-releasing factor-albumin bioconjugate (CJC-1295)." Drug Metab Dispos, 2005.
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See Also

cjc-1295-no-dacipamorelinsermorelinghrp-6hexarelin
Categories: Growth HormoneGHRHLong-ActingWADA Prohibited
More in Growth Hormone View all →
CJC-1295 863288-34-0 CJC-1295 No-DAC Ghrelin GHRP-1 GHRP-2 158861-67-7 GHRP-6 87616-84-0 Hexarelin 140703-51-1 IGF-1 DES
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Data Sources & External References
⬡ PubMed / NCBI, Research Literature ⬡ NCBI, Full-Text Articles ⬡ PubChem, Chemical Database
Source: peer-reviewed literature  ·  Domain: ascendpeptide.org
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