FDA-APPROVED BRAND
Wegovy Dose Calculator and Titration ScheduleActive ingredient: Semaglutide
Quick answer: Wegovy (semaglutide) titrates from 0.25 mg at week 1 to a 2.4 mg maintenance dose once weekly subcutaneously.
Fast facts
Active
Semaglutide
Maker
Novo Nordisk
FDA Approval
2021
Indication
Chronic weight management (BMI 30+, or 27+ with weight-related comorbidity)
Form
Single-dose subcutaneous pen, 0.25 / 0.5 / 1.0 / 1.7 / 2.4 mg
Titration schedule
| Phase | Dose | Frequency | Route |
|---|---|---|---|
| Week 1-4 | 0.25 mg | 1 pen / week | SC |
| Week 5-8 | 0.5 mg | 1 pen / week | SC |
| Week 9-12 | 1 mg | 1 pen / week | SC |
| Week 13-16 | 1.7 mg | 1 pen / week | SC |
| Week 17+ | 2.4 mg | 1 pen / week | SC |
Efficacy in clinical trials
STEP-1 trial: ~14.9% mean body weight loss at 68 weeks vs ~2.4% placebo
Side effects timeline
GI events (nausea, vomiting, diarrhea, constipation) peak weeks 1-3 of each titration step. Slower titration reduces severity.
Cost and access
~$1,350 / month US list price; insurance coverage varies by plan
Open Semaglutide Dose Calculator → Compare GLP-1 titration schedules side by sideFrequently asked
What is the standard Wegovy titration schedule?
Wegovy starts at 0.25 mg once weekly and steps up over 20 weeks to a maintenance dose of 2.4 mg once weekly. The slow ramp reduces GI side effects.
How long does it take to reach the target Wegovy dose?
5 titration steps of about four weeks each, so approximately 20 weeks (roughly 5 months) from the first injection to maintenance. Researchers can extend any single step if side effects are limiting.
What if I miss a dose of Wegovy?
If a Wegovy dose is missed and the next scheduled dose is more than two days away, take the missed dose as soon as possible. If less than two days remain, skip the missed dose and resume the schedule. Do not double up.
What are the common side effects of Wegovy?
GI events (nausea, vomiting, diarrhea, constipation) peak weeks 1-3 of each titration step. Slower titration reduces severity.
Is Wegovy the same as Ozempic?
Wegovy and Ozempic both contain the same active molecule (semaglutide). They differ in FDA indication (Wegovy = chronic weight management; Ozempic = Type 2 diabetes) and pen strengths offered. Wegovy maintenance dose is 2.4 mg/week; Ozempic typically maintains at 1.0 or 2.0 mg/week.
Related
For research informational use only. Not medical advice. Wegovy is a registered trademark of Novo Nordisk. Consult a qualified healthcare provider before any clinical decision. ASCEND, ascendpeptide.org