FDA-APPROVED BRAND
Ozempic Dose Calculator and Titration ScheduleActive ingredient: Semaglutide
Quick answer: Ozempic (semaglutide) titrates from 0.25 mg at week 1 to a 2 mg maintenance dose once weekly subcutaneously.
Fast facts
Active
Semaglutide
Maker
Novo Nordisk
FDA Approval
2017
Indication
Type 2 diabetes glycemic control; CV risk reduction in T2D with established CV disease
Form
Multi-dose subcutaneous pen, 0.25 / 0.5 / 1 / 2 mg
Titration schedule
| Phase | Dose | Frequency | Route |
|---|---|---|---|
| Week 1-4 | 0.25 mg | 1 pen / week | SC |
| Week 5+ | 0.5 mg | 1 pen / week | SC |
| Week 9+ | 1 mg | 1 pen / week | SC |
| Week 13+ | 2 mg | 1 pen / week | SC |
Efficacy in clinical trials
SUSTAIN trial program: HbA1c reduction 1.5 to 1.8 percentage points at maintenance dose
Side effects timeline
Same GI profile as Wegovy. Hypoglycemia risk when combined with sulfonylureas or insulin.
Cost and access
~$900 / month US list price; T2D indication typically gets insurance coverage
Open Semaglutide Dose Calculator → Compare GLP-1 titration schedules side by sideFrequently asked
What is the standard Ozempic titration schedule?
Ozempic starts at 0.25 mg once weekly and steps up over 16 weeks to a maintenance dose of 2 mg once weekly. The slow ramp reduces GI side effects.
How long does it take to reach the target Ozempic dose?
4 titration steps of about four weeks each, so approximately 16 weeks (roughly 4 months) from the first injection to maintenance. Researchers can extend any single step if side effects are limiting.
What if I miss a dose of Ozempic?
If a Ozempic dose is missed and the next scheduled dose is more than two days away, take the missed dose as soon as possible. If less than two days remain, skip the missed dose and resume the schedule. Do not double up.
What are the common side effects of Ozempic?
Same GI profile as Wegovy. Hypoglycemia risk when combined with sulfonylureas or insulin.
Is Ozempic the same as Ozempic?
Ozempic and Wegovy are both semaglutide. Ozempic is FDA-approved for Type 2 diabetes; Wegovy is approved for chronic weight management. Maximum maintenance doses differ (Ozempic up to 2.0 mg; Wegovy up to 2.4 mg).
Related
For research informational use only. Not medical advice. Ozempic is a registered trademark of Novo Nordisk. Consult a qualified healthcare provider before any clinical decision. ASCEND, ascendpeptide.org