Compound Semaglutide Dose Calculator and Titration ScheduleActive ingredient: Semaglutide
Quick answer: Compound Semaglutide (semaglutide) titrates from 0.25 mg at week 1 to a 2.4 mg maintenance dose once weekly subcutaneously. At the ASCEND standard 5 mg vial + 1 mL BAC water reconstitution (5 mg/mL), the 2.4 mg target dose equals 0.48 mL or 48 IU on a 100-unit insulin syringe.
2.4 mg semaglutide on a 100-unit insulin syringe
Fast facts
Active
Semaglutide
Maker
Compounding pharmacies (503A / 503B)
FDA Approval
Not FDA-approved as finished product
Indication
Research / off-label use only. Not FDA-approved as a finished drug product.
Form
Lyophilized vial (commonly 5 mg or 10 mg) + bacteriostatic water for reconstitution. Standard ASCEND default: 5 mg vial + 1 mL BAC water = 5 mg/mL.
Titration schedule
Phase
Dose
Volume
IU (100u)
Week 1-4
0.25 mg
0.05 mL
5 IU
Week 5-8
0.5 mg
0.1 mL
10 IU
Week 9-12
1 mg
0.2 mL
20 IU
Week 13-16
1.7 mg
0.34 mL
34 IU
Week 17+
2.4 mg
0.48 mL
48 IU
Efficacy in clinical trials
Compounded semaglutide is the same active molecule as Wegovy/Ozempic; clinical efficacy expectations track brand-product trial data when correctly compounded.
Side effects timeline
Same GI profile as branded semaglutide. Additional risks include compounding-pharmacy quality variability; verify Certificate of Analysis before use.
Cost and access
Historically $200 to $400 / month from 503A pharmacies during the FDA shortage. The FDA declared the semaglutide shortage resolved in early 2025, restricting routine compounding; supply is now narrower.
Important. Compounded semaglutide is not FDA-approved as a finished drug product. The FDA declared the brand-product shortage resolved in 2024 to early 2025, narrowing the legal scope for 503A compounding. Always verify the Certificate of Analysis from the supplying pharmacy and consult a qualified clinician.
What is the standard Compound Semaglutide titration schedule?
Compound Semaglutide starts at 0.25 mg once weekly and steps up over 20 weeks to a maintenance dose of 2.4 mg once weekly. The slow ramp reduces GI side effects.
How long does it take to reach the target Compound Semaglutide dose?
5 titration steps of about four weeks each, so approximately 20 weeks (roughly 5 months) from the first injection to maintenance. Researchers can extend any single step if side effects are limiting.
How do I reconstitute compounded semaglutide?
Standard ASCEND default: add 1 mL of bacteriostatic water to a 5 mg lyophilized vial, yielding 5 mg/mL. A 2.4 mg target dose then equals 0.48 mL, which is 48 IU on a 100-unit U-100 insulin syringe. Always verify the vial's Certificate of Analysis before use.
What are the common side effects of Compound Semaglutide?
Same GI profile as branded semaglutide. Additional risks include compounding-pharmacy quality variability; verify Certificate of Analysis before use.
Is Compound Semaglutide the same as Ozempic?
Ozempic and Wegovy are both semaglutide. Ozempic is FDA-approved for Type 2 diabetes; Wegovy is approved for chronic weight management. Maximum maintenance doses differ (Ozempic up to 2.0 mg; Wegovy up to 2.4 mg).
For research informational use only. Not medical advice. Compound Semaglutide is compounded by 503A or 503B pharmacies and is not an FDA-approved finished drug product. Consult a qualified healthcare provider before any clinical decision. ASCEND, ascendpeptide.org