⚖ Head-to-Head · Melanocortin Agonists

PT-141 vs Melanotan II

Mechanism, half-life, dosing & research status compared side-by-side.

PT-141
Sexual Health & Melanocortin
Approved
Sexual HealthMelanocortinFDA Approved
PT-141 (Bremelanotide) is a cyclic heptapeptide analog of Melanotan II and alpha-MSH that acts on melanocortin receptors (MC1R, MC3R, MC4R) in the central nervous system to activate sexual arousal pathways. Unlike PDE5 i…
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Melanotan II
Skin & Cosmetic
Not Approved
MelanocortinSexual HealthTanningLibido
Melanotan II (MT-II) is a synthetic analog of alpha-MSH (alpha-melanocyte-stimulating hormone) that non-selectively activates melanocortin receptors MC1R through MC5R. It produces accelerated skin tanning via MC1R stimul…
Full Melanotan II profile →
Technical Specs Comparison
MetricPT-141Melanotan II
Research Status FDA Approved Research Use
Molecular Weight 1,025.2 Da 1,024.2 Da
Half-Life ~2.7 hours ~1.5 hours
Peak Time ~45–60 min -
Typical Dose 1.75 mg (FDA); 1–2 mg research 250–500 µg (starting); up to 1,000 µg
Frequency As needed (max 1× per 24h) Daily initially; 2–3x/week maintenance
Route Subcutaneous Subcutaneous
Amino Acids 7 7
WADA Status Not Listed Not Listed
FDA Status Approved Not Approved
Stack Compatibility & Key Differences
PT-141 has FDA approval; Melanotan II is research-only.
Frequently Asked Questions
What is the difference between PT-141 and Melanotan II?
PT-141: PT-141 (Bremelanotide) is a cyclic heptapeptide analog of Melanotan II and alpha-MSH that acts on melanocortin receptors (MC1R, MC3R, MC4R) in the central nervous system to activate sexual arousal pathways. Unlike PDE5 i… Melanotan II: Melanotan II (MT-II) is a synthetic analog of alpha-MSH (alpha-melanocyte-stimulating hormone) that non-selectively activates melanocortin receptors MC1R through MC5R. It produces accelerated skin tanning via MC1R stimul…
Can you stack PT-141 and Melanotan II?
PT-141 has FDA approval; Melanotan II is research-only.
Which has a longer half-life, PT-141 or Melanotan II?
PT-141 half-life: ~2.7 hours. Melanotan II half-life: ~1.5 hours.
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Verified Scientific Data
All specifications on this page are sourced from peer-reviewed literature and primary research. Half-life values, dosing ranges, and mechanism data are cross-referenced against published studies. Last audited 2026-06-07.
● Peer-reviewed sources ● Audit timestamp: 2026-06-07 ● Data version: ASCEND Wiki 2026
Data sourced from ASCEND Wiki · PT-141 profile · Melanotan II profile · All comparisons
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