⚖ Head-to-Head · Oral vs Injectable GH Axis

MK-677 vs Ipamorelin

Mechanism, half-life, dosing & research status compared side-by-side.

MK-677
Growth Hormone & IGF
Not Approved
Growth HormoneOralNon-PeptideWADA ProhibitedPhase II
MK-677 (ibutamoren) is an orally active, non-peptide ghrelin receptor agonist (GHS-R1a) that stimulates GH release from the pituitary without requiring injection. It was developed by Merck and advanced through Phase II t…
Full MK-677 profile →
Ipamorelin
Growth Hormone
Not Approved
Growth HormoneRecoveryBody CompositionAnti-aging
Ipamorelin is a synthetic pentapeptide growth hormone releasing peptide (GHRP) that selectively stimulates GH secretion from pituitary somatotrophs. Unlike other GHRPs (GHRP-2, GHRP-6, Hexarelin), Ipamorelin does not sig…
Full Ipamorelin profile →
Technical Specs Comparison
MetricMK-677Ipamorelin
Research Status Phase II (Discontinued) Extensively Studied
Molecular Weight 624.8 Da 711.9 Da
Half-Life ~24 hours ~2 hours
Peak Time - ~60 min
Typical Dose 10–25 mg 100–300 µg
Frequency Once daily 1–3× daily
Route Oral Subcutaneous
Amino Acids - 5
WADA Status Prohibited Prohibited
FDA Status Not Approved Not Approved
Stack Compatibility & Key Differences
Both are active research compounds. See individual pages for full protocol data.
PK Plotter
Visualize Ipamorelin plasma levels → Plot →
Frequently Asked Questions
What is the difference between MK-677 and Ipamorelin?
MK-677: MK-677 (ibutamoren) is an orally active, non-peptide ghrelin receptor agonist (GHS-R1a) that stimulates GH release from the pituitary without requiring injection. It was developed by Merck and advanced through Phase II t… Ipamorelin: Ipamorelin is a synthetic pentapeptide growth hormone releasing peptide (GHRP) that selectively stimulates GH secretion from pituitary somatotrophs. Unlike other GHRPs (GHRP-2, GHRP-6, Hexarelin), Ipamorelin does not sig…
Can you stack MK-677 and Ipamorelin?
Both are active research compounds. See individual pages for full protocol data.
Which has a longer half-life, MK-677 or Ipamorelin?
MK-677 half-life: ~24 hours. Ipamorelin half-life: ~2 hours.
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Verified Scientific Data
All specifications on this page are sourced from peer-reviewed literature and primary research. Half-life values, dosing ranges, and mechanism data are cross-referenced against published studies. Last audited 2026-06-07.
● Peer-reviewed sources ● Audit timestamp: 2026-06-07 ● Data version: ASCEND Wiki 2026
Data sourced from ASCEND Wiki · MK-677 profile · Ipamorelin profile · All comparisons
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