⚖ Head-to-Head · Immune Peptides

LL-37 vs Thymosin Alpha-1

Mechanism, half-life, dosing & research status compared side-by-side.

LL-37
Immune & Antimicrobial
Not Approved
AntimicrobialWound HealingImmuneInnate Immunity
LL-37 is the only human cathelicidin - the C-terminal 37-amino acid fragment of the precursor protein hCAP-18, cleaved by proteases at sites of infection and inflammation. It is produced primarily by neutrophils, epithel…
Full LL-37 profile →
Thymosin Alpha-1
Immune Support
Not Approved (US)
Immune SupportAnti-agingAntiviralLongevity
Thymosin Alpha-1 (TA1) is a 28-amino acid peptide naturally secreted by thymic epithelial cells, commercially available as Thymalfasin (Zadaxin). It is approved as a pharmaceutical drug in over 35 countries (including Ch…
Full Thymosin Alpha-1 profile →
Technical Specs Comparison
MetricLL-37Thymosin Alpha-1
Research Status Extensively Studied Extensively Studied
Molecular Weight 4,493 Da 3,108 Da
Half-Life ~minutes (plasma); local effects sustained ~2 hours
Peak Time ~30 min (SC) ~1–2 hours
Typical Dose 50–200 µg 0.8–1.6 mg
Frequency Once or twice daily 2× weekly or daily
Route Topical / Intranasal / Subcutaneous Subcutaneous
Amino Acids 37 28
WADA Status Not Listed Not Listed
FDA Status Not Approved Not Approved (US)
Stack Compatibility & Key Differences
Both are active research compounds. See individual pages for full protocol data.
Frequently Asked Questions
What is the difference between LL-37 and Thymosin Alpha-1?
LL-37: LL-37 is the only human cathelicidin - the C-terminal 37-amino acid fragment of the precursor protein hCAP-18, cleaved by proteases at sites of infection and inflammation. It is produced primarily by neutrophils, epithel… Thymosin Alpha-1: Thymosin Alpha-1 (TA1) is a 28-amino acid peptide naturally secreted by thymic epithelial cells, commercially available as Thymalfasin (Zadaxin). It is approved as a pharmaceutical drug in over 35 countries (including Ch…
Can you stack LL-37 and Thymosin Alpha-1?
Both are active research compounds. See individual pages for full protocol data.
Which has a longer half-life, LL-37 or Thymosin Alpha-1?
LL-37 half-life: ~minutes (plasma); local effects sustained. Thymosin Alpha-1 half-life: ~2 hours.
Verified Scientific Data
All specifications on this page are sourced from peer-reviewed literature and primary research. Half-life values, dosing ranges, and mechanism data are cross-referenced against published studies. Last audited 2026-06-07.
Peer-reviewed sources Audit timestamp: 2026-06-07 Data version: ASCEND Wiki 2026
Data sourced from ASCEND Wiki · LL-37 profile · Thymosin Alpha-1 profile · All comparisons
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