⚖ Head-to-Head · Longevity Proteins

Klotho vs Epithalon

Mechanism, half-life, dosing & research status compared side-by-side.

Klotho
Longevity & Anti-Aging
Not Approved
LongevityAnti-AgingKidneyEpigeneticPreclinical
Klotho is an anti-aging protein encoded by the KL gene, named after the Greek Fate who spins the thread of life. α-Klotho exists as a transmembrane protein primarily in the kidney and choroid plexus, and is shed as a sol…
Full Klotho profile →
Epithalon
Longevity & Telomere
Not Approved
LongevityTelomereAnti-agingPineal
Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal gland bioregulator Epithalamin. It was developed by the St. Petersburg Institute of Biogerontology by Professor Vladimir Khavinso…
Full Epithalon profile →
Technical Specs Comparison
MetricKlothoEpithalon
Research Status Preclinical Extensively Studied
Molecular Weight ~130 kDa (full); ~65–70 kDa (shed fragment) 390.3 Da
Half-Life Hours (shed fragment in serum) ~30 min
Peak Time - ~20–30 min
Typical Dose - 5–10 mg
Frequency - Once daily × 10–20 days (cycle)
Route IV / Subcutaneous (research) Subcutaneous / IV
Amino Acids - 4
WADA Status Not Listed Not Listed
FDA Status Not Approved Not Approved
Stack Compatibility & Key Differences
Both are active research compounds. See individual pages for full protocol data.
PK Plotter
Visualize Epithalon plasma levels → Plot →
Frequently Asked Questions
What is the difference between Klotho and Epithalon?
Klotho: Klotho is an anti-aging protein encoded by the KL gene, named after the Greek Fate who spins the thread of life. α-Klotho exists as a transmembrane protein primarily in the kidney and choroid plexus, and is shed as a sol… Epithalon: Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal gland bioregulator Epithalamin. It was developed by the St. Petersburg Institute of Biogerontology by Professor Vladimir Khavinso…
Can you stack Klotho and Epithalon?
Both are active research compounds. See individual pages for full protocol data.
Which has a longer half-life, Klotho or Epithalon?
Klotho half-life: Hours (shed fragment in serum). Epithalon half-life: ~30 min.
Verified Scientific Data
All specifications on this page are sourced from peer-reviewed literature and primary research. Half-life values, dosing ranges, and mechanism data are cross-referenced against published studies. Last audited 2026-06-07.
Peer-reviewed sources Audit timestamp: 2026-06-07 Data version: ASCEND Wiki 2026
Data sourced from ASCEND Wiki · Klotho profile · Epithalon profile · All comparisons
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