⚖ Head-to-Head · Anti-Aging Mechanisms

GHK-Cu vs Epithalon

Mechanism, half-life, dosing & research status compared side-by-side.

GHK-Cu
Skin & Connective Tissue
Not Approved (Injectable)
SkinHealingAnti-agingConnective Tissue
GHK-Cu (Glycine-Histidine-Lysine Copper Complex) is a naturally occurring tripeptide with high affinity for copper(II) ions, found in human plasma, saliva, and urine. Plasma levels decline significantly with age - from ~…
Full GHK-Cu profile →
Epithalon
Longevity & Telomere
Not Approved
LongevityTelomereAnti-agingPineal
Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal gland bioregulator Epithalamin. It was developed by the St. Petersburg Institute of Biogerontology by Professor Vladimir Khavinso…
Full Epithalon profile →
Technical Specs Comparison
MetricGHK-CuEpithalon
Research Status Extensively Studied Extensively Studied
Molecular Weight 340.4 Da (free), ~402 Da (complex) 390.3 Da
Half-Life ~30 min (plasma) ~30 min
Peak Time ~20 min ~20–30 min
Typical Dose 1–2 mg 5–10 mg
Frequency Once daily Once daily × 10–20 days (cycle)
Route Subcutaneous / Topical Subcutaneous / IV
Amino Acids 3 4
WADA Status Not Listed Not Listed
FDA Status Not Approved (Injectable) Not Approved
Stack Compatibility & Key Differences
Both are active research compounds. See individual pages for full protocol data.
PK Plotter · Visualize plasma levels over time
Plot GHK-Cu → Plot Epithalon →
Frequently Asked Questions
What is the difference between GHK-Cu and Epithalon?
GHK-Cu: GHK-Cu (Glycine-Histidine-Lysine Copper Complex) is a naturally occurring tripeptide with high affinity for copper(II) ions, found in human plasma, saliva, and urine. Plasma levels decline significantly with age - from ~… Epithalon: Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal gland bioregulator Epithalamin. It was developed by the St. Petersburg Institute of Biogerontology by Professor Vladimir Khavinso…
Can you stack GHK-Cu and Epithalon?
Both are active research compounds. See individual pages for full protocol data.
Which has a longer half-life, GHK-Cu or Epithalon?
GHK-Cu half-life: ~30 min (plasma). Epithalon half-life: ~30 min.
Verified Scientific Data
All specifications on this page are sourced from peer-reviewed literature and primary research. Half-life values, dosing ranges, and mechanism data are cross-referenced against published studies. Last audited 2026-06-07.
Peer-reviewed sources Audit timestamp: 2026-06-07 Data version: ASCEND Wiki 2026
Data sourced from ASCEND Wiki · GHK-Cu profile · Epithalon profile · All comparisons
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