⚖ Head-to-Head · Senolytic vs Anti-Aging

FOXO4-DRI vs Epithalon

Mechanism, half-life, dosing & research status compared side-by-side.

FOXO4-DRI
Longevity & Anti-Aging
Not Approved
LongevitySenolyticAnti-AgingPreclinicalD-Peptide
FOXO4-DRI is a D-retro-inverso peptide that selectively disrupts the interaction between FOXO4 and p53 in senescent cells. In normal cycling cells, p53 is free to trigger apoptosis when needed. In senescent cells, FOXO4 …
Full FOXO4-DRI profile →
Epithalon
Longevity & Telomere
Not Approved
LongevityTelomereAnti-agingPineal
Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal gland bioregulator Epithalamin. It was developed by the St. Petersburg Institute of Biogerontology by Professor Vladimir Khavinso…
Full Epithalon profile →
Technical Specs Comparison
MetricFOXO4-DRIEpithalon
Research Status Preclinical Extensively Studied
Molecular Weight - 390.3 Da
Half-Life - ~30 min
Peak Time - ~20–30 min
Typical Dose 5 mg/kg (animal models) 5–10 mg
Frequency 3x weekly (research cycles) Once daily × 10–20 days (cycle)
Route Intraperitoneal / Subcutaneous (research) Subcutaneous / IV
Amino Acids - 4
WADA Status Not Listed Not Listed
FDA Status Not Approved Not Approved
Stack Compatibility & Key Differences
Both are active research compounds. See individual pages for full protocol data.
PK Plotter
Visualize Epithalon plasma levels → Plot →
Frequently Asked Questions
What is the difference between FOXO4-DRI and Epithalon?
FOXO4-DRI: FOXO4-DRI is a D-retro-inverso peptide that selectively disrupts the interaction between FOXO4 and p53 in senescent cells. In normal cycling cells, p53 is free to trigger apoptosis when needed. In senescent cells, FOXO4 … Epithalon: Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal gland bioregulator Epithalamin. It was developed by the St. Petersburg Institute of Biogerontology by Professor Vladimir Khavinso…
Can you stack FOXO4-DRI and Epithalon?
Both are active research compounds. See individual pages for full protocol data.
Which has a longer half-life, FOXO4-DRI or Epithalon?
FOXO4-DRI half-life: - . Epithalon half-life: ~30 min.
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Verified Scientific Data
All specifications on this page are sourced from peer-reviewed literature and primary research. Half-life values, dosing ranges, and mechanism data are cross-referenced against published studies. Last audited 2026-06-07.
● Peer-reviewed sources ● Audit timestamp: 2026-06-07 ● Data version: ASCEND Wiki 2026
Data sourced from ASCEND Wiki · FOXO4-DRI profile · Epithalon profile · All comparisons
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