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Epithalon vs NAD+

Mechanism, half-life, dosing & research status compared side-by-side.

Epithalon
Longevity & Telomere
Not Approved
LongevityTelomereAnti-agingPineal
Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal gland bioregulator Epithalamin. It was developed by the St. Petersburg Institute of Biogerontology by Professor Vladimir Khavinso…
Full Epithalon profile →
NAD+
Metabolic & Mitochondrial
Not Approved (drug use)
MitochondrialLongevityAnti-AgingNAD+IV Therapy
NAD+ (Nicotinamide Adenine Dinucleotide) is the oxidized form of the essential coenzyme NAD, present in every living cell. It is critical for mitochondrial energy production (as a hydrogen carrier in the electron transpo…
Full NAD+ profile →
Technical Specs Comparison
MetricEpithalonNAD+
Research Status Extensively Studied Widely Studied
Molecular Weight 390.3 Da 663.4 Da
Half-Life ~30 min Very short (direct IV); precursors have hours-long kinetics
Peak Time ~20–30 min -
Typical Dose 5–10 mg 250–1,000 mg (IV)
Frequency Once daily × 10–20 days (cycle) 2–3x weekly (IV therapy); daily (oral precursors)
Route Subcutaneous / IV IV / IM / Oral (as precursors NMN, NR)
Amino Acids 4 -
WADA Status Not Listed Not Listed
FDA Status Not Approved Not Approved (drug use)
Stack Compatibility & Key Differences
Both are active research compounds. See individual pages for full protocol data.
PK Plotter · Visualize plasma levels over time
Plot Epithalon → Plot NAD+ →
Frequently Asked Questions
What is the difference between Epithalon and NAD+?
Epithalon: Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal gland bioregulator Epithalamin. It was developed by the St. Petersburg Institute of Biogerontology by Professor Vladimir Khavinso… NAD+: NAD+ (Nicotinamide Adenine Dinucleotide) is the oxidized form of the essential coenzyme NAD, present in every living cell. It is critical for mitochondrial energy production (as a hydrogen carrier in the electron transpo…
Can you stack Epithalon and NAD+?
Both are active research compounds. See individual pages for full protocol data.
Which has a longer half-life, Epithalon or NAD+?
Epithalon half-life: ~30 min. NAD+ half-life: Very short (direct IV); precursors have hours-long kinetics.
Verified Scientific Data
All specifications on this page are sourced from peer-reviewed literature and primary research. Half-life values, dosing ranges, and mechanism data are cross-referenced against published studies. Last audited 2026-06-07.
Peer-reviewed sources Audit timestamp: 2026-06-07 Data version: ASCEND Wiki 2026
Data sourced from ASCEND Wiki · Epithalon profile · NAD+ profile · All comparisons
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