Metabolic & Weight
CagriSema Dosing & Reconstitution Calculator
Phase 3 REDEFINE-1 combination protocol: Cagrilintide (amylin analog) + Semaglutide (GLP-1 agonist) at 2.4/2.4 mg weekly. Achieved ~22.7% mean body weight loss at 68 weeks.
TL;DR - CagriSema is a metabolic & weight peptide with a typical starting dose of 2.4 mg. For a 10 mg vial, add 3 mL bacteriostatic water to yield 3.3 mg/mL.
2.4 mg
Start Dose
10 mg
Vial
3 mL
BAC Water
3.3
mg/mL
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Frequently Asked
How do I reconstitute CagriSema?
Add 3 mL of bacteriostatic water to a 10 mg vial, injecting slowly down the inside wall. Swirl gently; never shake. This yields a concentration of 3.3 mg/mL.
What is the recommended dose of CagriSema?
A typical research dose is 2.4 mg. Consult the ASCEND calculator for your specific vial concentration and draw volume.
How many doses are in a CagriSema vial?
A 10 mg vial reconstituted with 3 mL BAC water yields approximately 4 doses at 2.4 mg each.
How many IU is 2.4 mg of CagriSema on a syringe?
With a 10 mg vial reconstituted in 3 mL bacteriostatic water, the concentration is 3.3 mg/mL. For a 2.4 mg dose: Volume = 2.4 mg ÷ 3.3 mg/mL = 0.72 mL. Draw to the 72 line on a 100-unit insulin syringe. You can adjust these values in the ASCEND calculator for any vial size.
What does a CagriSema dosage calculator do?
A CagriSema dosage calculator converts your vial size and BAC water volume into an exact syringe draw in IU. Enter your vial strength (10 mg), reconstitution volume (3 mL), and target dose to get the precise line to draw on an insulin syringe.
What is the CagriSema reconstitution calculator formula?
Draw volume (mL) = Dose (mg) divided by Concentration (mg/mL). For a 10 mg vial with 3 mL BAC water: concentration = 3.3 mg/mL. For a 2.4 mg dose, the ASCEND calculator gives the exact IU line on your syringe instantly.
Peptide Intelligence
What is CagriSema and how does it work?
CagriSema is a combination protocol pairing Cagrilintide (a long-acting amylin analog) with Semaglutide (a GLP-1 receptor agonist). Cagrilintide works through amylin/calcitonin receptors to slow gastric emptying and reduce glucagon, while Semaglutide activates GLP-1 receptors to suppress appetite. Their complementary receptor targets produce additive weight loss exceeding either compound alone.
What weight loss results did CagriSema show in REDEFINE-1?
The Phase 3 REDEFINE-1 trial showed approximately 22.7% mean body weight loss at 68 weeks with CagriSema 2.4/2.4 mg weekly. This exceeded semaglutide alone (~15%) and positions CagriSema among the most efficacious pharmacological weight-loss interventions studied to date.
What is the CagriSema titration schedule?
Both components are escalated in parallel: start at 0.25/0.25 mg weekly (weeks 1–4), then 0.5/0.5 mg (weeks 5–8), 1.0/1.0 mg (weeks 9–12), 1.7/1.7 mg (weeks 13–16), reaching maintenance of 2.4/2.4 mg at week 17 onward. Slower escalation reduces nausea and GI side effects during dose ramp-up.
Also Explore
Research Guides
Bacteriostatic Water Guide
What it is & why it matters for reconstitution
How Much BAC Water for CagriSema?
10 mg vial reconstitution recipe + concentration table
CagriSema on Insulin Syringe
2.4 mg draw on 30u / 50u / 100u syringes
Insulin Syringe Guide
Choosing the right gauge & volume for your draw
Multi-Lab Verification Standard
How ASCEND ensures dosing accuracy
Primary Sources
CagriSema Phase 1b (Lancet 2021)
REDEFINE-1 Phase 3 (ClinicalTrials)
ClinicalTrials NCT05066854
Data last reviewed 2026-06-09 · Methodology →
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