METABOLIC & WEIGHT LOSS STACK
Retatrutide + CagrilintideTriple agonist + amylin analog
Synergy: Retatrutide activates GIP, GLP-1, and glucagon receptors; Cagrilintide is a long-acting amylin analog that slows gastric emptying and suppresses glucagon. The combination is researched for additive weight loss beyond what triple agonism alone provides.
Stack components
Retatrutide
Metabolic & Weight
Triple GIP/GLP-1/glucagon receptor agonist. Phase 3 TRIUMPH titration: 0.5 mg up to 12 mg over 24 weeks.
0.5 mg draw on 100u syringe
Cagrilintide
Metabolic & Weight
Long-acting amylin analog promoting satiety. Combined with semaglutide (CagriSema), REDEFINE-1 showed ~22.7% weight loss.
0.3 mg draw on 100u syringe
Injection timing
Both once weekly SC, ideally on the same day. Inject at separate sites if drawn separately.
Same syringe or separate?
Independent reconstitution; same-syringe stability not formally established.
Typical cycle length
Titration over 24+ weeks, then maintenance dosing per research protocol.
Research use only. Peptide stacks compound effects and side-effect risk. Always verify Certificates of Analysis for each peptide. Consult a qualified clinician before initiating any combined protocol.
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Frequently asked
What does the Retatrutide + Cagrilintide stack do?
Retatrutide activates GIP, GLP-1, and glucagon receptors; Cagrilintide is a long-acting amylin analog that slows gastric emptying and suppresses glucagon. The combination is researched for additive weight loss beyond what triple agonism alone provides.
When should Retatrutide and Cagrilintide be injected?
Both once weekly SC, ideally on the same day. Inject at separate sites if drawn separately.
Can Retatrutide and Cagrilintide be drawn into the same syringe?
Independent reconstitution; same-syringe stability not formally established.
How long is a typical Retatrutide + Cagrilintide cycle?
Titration over 24+ weeks, then maintenance dosing per research protocol.
What dose of Retatrutide pairs with Cagrilintide?
Standard ASCEND reference dose for Retatrutide: 0.5 mg from a 10 mg vial reconstituted with 2 mL bacteriostatic water (5 mg/mL). Draw volume at this concentration: 0.1 mL, which is 10 IU on a 100-unit insulin syringe. Adjust to the research protocol you are following.
Related
For research informational use only. Not medical advice. Combination protocols have not been formally validated by the FDA. Consult a qualified healthcare provider before initiating any peptide stack.