⚖ Head-to-Head · Dual vs Triple Agonist

Tirzepatide vs Retatrutide

Mechanism, half-life, dosing & research status compared side-by-side.

Tirzepatide
Metabolic / Dual Incretin Agonist
Approved (T2D 2022, obesity 2023)
GLP-1 AgonistGIP AgonistFDA ApprovedWeight ManagementMetabolic
Tirzepatide is a first-in-class dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist developed by Eli Lilly. By simultaneously activating both incretin receptors, t…
Full Tirzepatide profile →
Retatrutide
Metabolic / Triple Incretin Agonist
Phase 3 (obesity, T2D); not yet approved
GLP-1 AgonistGIP AgonistGlucagon AgonistWeight ManagementMetabolicPhase 3
Retatrutide is a first-in-class triple receptor agonist developed by Eli Lilly that simultaneously activates GLP-1, GIP, and glucagon receptors. By adding glucagon receptor activity to the dual incretin mechanism of tirz…
Full Retatrutide profile →
Technical Specs Comparison
MetricTirzepatideRetatrutide
Research Status FDA Approved Phase 3 Clinical Trials
Molecular Weight 4813.47 Da ~4.4 kDa
Half-Life ~120 hours (5 days) ~6 days
Peak Time 8-72 hours post-injection 48-96 hours post-injection
Typical Dose 2.5-15 mg/week 1-24 mg/week (Phase 2); Phase 3 doses TBD
Frequency Once weekly Once weekly
Route Subcutaneous injection Subcutaneous injection
Amino Acids 39 36
WADA Status Not listed Not listed
FDA Status Approved (T2D 2022, obesity 2023) Phase 3 (obesity, T2D); not yet approved
Stack Compatibility & Key Differences
Tirzepatide has FDA approval; Retatrutide is research-only.
PK Plotter · Visualize plasma levels over time
Plot Tirzepatide → Plot Retatrutide →
Frequently Asked Questions
What is the difference between Tirzepatide and Retatrutide?
Tirzepatide: Tirzepatide is a first-in-class dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist developed by Eli Lilly. By simultaneously activating both incretin receptors, t… Retatrutide: Retatrutide is a first-in-class triple receptor agonist developed by Eli Lilly that simultaneously activates GLP-1, GIP, and glucagon receptors. By adding glucagon receptor activity to the dual incretin mechanism of tirz…
Can you stack Tirzepatide and Retatrutide?
Tirzepatide has FDA approval; Retatrutide is research-only.
Which has a longer half-life, Tirzepatide or Retatrutide?
Tirzepatide half-life: ~120 hours (5 days). Retatrutide half-life: ~6 days.
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Verified Scientific Data
All specifications on this page are sourced from peer-reviewed literature and primary research. Half-life values, dosing ranges, and mechanism data are cross-referenced against published studies. Last audited 2026-06-07.
● Peer-reviewed sources ● Audit timestamp: 2026-06-07 ● Data version: ASCEND Wiki 2026
Data sourced from ASCEND Wiki · Tirzepatide profile · Retatrutide profile · All comparisons
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