⚖ Head-to-Head · GLP-1 vs Dual Agonist

Semaglutide vs Tirzepatide

Mechanism, half-life, dosing & research status compared side-by-side.

Semaglutide
Metabolic / GLP-1 Agonist
Approved (T2D, obesity)
GLP-1 AgonistFDA ApprovedWeight ManagementMetabolicDiabetes
Semaglutide is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist developed by Novo Nordisk. Approved for type 2 diabetes management and chronic weight management, it has become one of the most widely prescri…
Full Semaglutide profile →
Tirzepatide
Metabolic / Dual Incretin Agonist
Approved (T2D 2022, obesity 2023)
GLP-1 AgonistGIP AgonistFDA ApprovedWeight ManagementMetabolic
Tirzepatide is a first-in-class dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist developed by Eli Lilly. By simultaneously activating both incretin receptors, t…
Full Tirzepatide profile →
Technical Specs Comparison
MetricSemaglutideTirzepatide
Research Status FDA Approved FDA Approved
Molecular Weight 4113.58 Da 4813.47 Da
Half-Life ~168 hours (7 days) ~120 hours (5 days)
Peak Time 1-3 days post-injection 8-72 hours post-injection
Typical Dose 0.25-2.4 mg/week (SC); 3-14 mg/day (oral) 2.5-15 mg/week
Frequency Once weekly (SC); once daily (oral) Once weekly
Route Subcutaneous injection; oral tablet Subcutaneous injection
Amino Acids 31 39
WADA Status Not listed Not listed
FDA Status Approved (T2D, obesity) Approved (T2D 2022, obesity 2023)
Stack Compatibility & Key Differences
Both are active research compounds. See individual pages for full protocol data.
PK Plotter · Visualize plasma levels over time
Plot Semaglutide → Plot Tirzepatide →
Frequently Asked Questions
What is the difference between Semaglutide and Tirzepatide?
Semaglutide: Semaglutide is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist developed by Novo Nordisk. Approved for type 2 diabetes management and chronic weight management, it has become one of the most widely prescri… Tirzepatide: Tirzepatide is a first-in-class dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist developed by Eli Lilly. By simultaneously activating both incretin receptors, t…
Can you stack Semaglutide and Tirzepatide?
Both are active research compounds. See individual pages for full protocol data.
Which has a longer half-life, Semaglutide or Tirzepatide?
Semaglutide half-life: ~168 hours (7 days). Tirzepatide half-life: ~120 hours (5 days).
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Verified Scientific Data
All specifications on this page are sourced from peer-reviewed literature and primary research. Half-life values, dosing ranges, and mechanism data are cross-referenced against published studies. Last audited 2026-06-07.
● Peer-reviewed sources ● Audit timestamp: 2026-06-07 ● Data version: ASCEND Wiki 2026
Data sourced from ASCEND Wiki · Semaglutide profile · Tirzepatide profile · All comparisons
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