⚖ Head-to-Head · Mitochondrial Peptides

MOTS-c vs SS-31

Mechanism, half-life, dosing & research status compared side-by-side.

MOTS-c
Mitochondrial & Longevity
Not Approved
MitochondrialLongevityExercise PerformanceEnergy
MOTS-c is a 16-amino acid mitochondrial-derived peptide (MDP) encoded within the 12S ribosomal RNA gene of the mitochondrial genome - making it unique among peptides as a mitochondrial, rather than nuclear, gene product.…
Full MOTS-c profile →
SS-31
Mitochondrial
Phase II/III
MitochondrialLongevityCardiacEnergy
SS-31 (Elamipretide) is a synthetic aromatic-cationic tetrapeptide that selectively concentrates in the inner mitochondrial membrane (IMM) due to its unique charge properties. It is the most advanced mitochondrial-target…
Full SS-31 profile →
Technical Specs Comparison
MetricMOTS-cSS-31
Research Status Extensively Studied Extensively Studied
Molecular Weight 2,174.6 Da 638.8 Da
Half-Life 4 hours ~2–4 hours
Peak Time ~1 hour ~30–60 min
Typical Dose 5–15 mg 1–5 mg
Frequency Daily or 3× per week Once daily
Route Subcutaneous Subcutaneous
Amino Acids 16 4
WADA Status Prohibited Not Listed
FDA Status Not Approved Phase II/III
Stack Compatibility & Key Differences
MOTS-c and SS-31 are commonly stacked - rated synergistic in research protocols.
PK Plotter · Visualize plasma levels over time
Plot MOTS-c → Plot SS-31 →
Frequently Asked Questions
What is the difference between MOTS-c and SS-31?
MOTS-c: MOTS-c is a 16-amino acid mitochondrial-derived peptide (MDP) encoded within the 12S ribosomal RNA gene of the mitochondrial genome - making it unique among peptides as a mitochondrial, rather than nuclear, gene product.… SS-31: SS-31 (Elamipretide) is a synthetic aromatic-cationic tetrapeptide that selectively concentrates in the inner mitochondrial membrane (IMM) due to its unique charge properties. It is the most advanced mitochondrial-target…
Can you stack MOTS-c and SS-31?
MOTS-c and SS-31 are commonly stacked - rated synergistic in research protocols.
Which has a longer half-life, MOTS-c or SS-31?
MOTS-c half-life: 4 hours. SS-31 half-life: ~2–4 hours.
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Verified Scientific Data
All specifications on this page are sourced from peer-reviewed literature and primary research. Half-life values, dosing ranges, and mechanism data are cross-referenced against published studies. Last audited 2026-06-07.
● Peer-reviewed sources ● Audit timestamp: 2026-06-07 ● Data version: ASCEND Wiki 2026
Data sourced from ASCEND Wiki · MOTS-c profile · SS-31 profile · All comparisons
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