⚖ Head-to-Head · Mitochondrial Peptides

Humanin vs MOTS-c

Mechanism, half-life, dosing & research status compared side-by-side.

Humanin
Mitochondrial & Longevity
Not Approved
MitochondrialLongevityAnti-agingAging
Humanin is a 21-amino acid mitochondrial-derived peptide (MDP) encoded within the 16S ribosomal RNA gene (MT-RNR2) of the mitochondrial genome - the same mitochondrial gene region that encodes MOTS-c. Discovered in 2001 …
Full Humanin profile →
MOTS-c
Mitochondrial & Longevity
Not Approved
MitochondrialLongevityExercise PerformanceEnergy
MOTS-c is a 16-amino acid mitochondrial-derived peptide (MDP) encoded within the 12S ribosomal RNA gene of the mitochondrial genome - making it unique among peptides as a mitochondrial, rather than nuclear, gene product.…
Full MOTS-c profile →
Technical Specs Comparison
MetricHumaninMOTS-c
Research Status Extensively Studied Extensively Studied
Molecular Weight ~2,687 Da 2,174.6 Da
Half-Life ~2–4 hours 4 hours
Peak Time ~1 hour ~1 hour
Typical Dose 2–10 mg 5–15 mg
Frequency Once daily or 3× weekly Daily or 3× per week
Route Subcutaneous Subcutaneous
Amino Acids 21 16
WADA Status Not Listed Prohibited
FDA Status Not Approved Not Approved
Stack Compatibility & Key Differences
Humanin and MOTS-c are commonly stacked - rated synergistic in research protocols.
PK Plotter
Visualize MOTS-c plasma levels → Plot →
Frequently Asked Questions
What is the difference between Humanin and MOTS-c?
Humanin: Humanin is a 21-amino acid mitochondrial-derived peptide (MDP) encoded within the 16S ribosomal RNA gene (MT-RNR2) of the mitochondrial genome - the same mitochondrial gene region that encodes MOTS-c. Discovered in 2001 … MOTS-c: MOTS-c is a 16-amino acid mitochondrial-derived peptide (MDP) encoded within the 12S ribosomal RNA gene of the mitochondrial genome - making it unique among peptides as a mitochondrial, rather than nuclear, gene product.…
Can you stack Humanin and MOTS-c?
Humanin and MOTS-c are commonly stacked - rated synergistic in research protocols.
Which has a longer half-life, Humanin or MOTS-c?
Humanin half-life: ~2–4 hours. MOTS-c half-life: 4 hours.
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Verified Scientific Data
All specifications on this page are sourced from peer-reviewed literature and primary research. Half-life values, dosing ranges, and mechanism data are cross-referenced against published studies. Last audited 2026-06-07.
● Peer-reviewed sources ● Audit timestamp: 2026-06-07 ● Data version: ASCEND Wiki 2026
Data sourced from ASCEND Wiki · Humanin profile · MOTS-c profile · All comparisons
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