⚖ Head-to-Head · Nootropic Peptides

Dihexa vs Semax

Mechanism, half-life, dosing & research status compared side-by-side.

Dihexa
Nootropic / Neurogenic
Not approved; preclinical stage
NootropicNeurogenicPreclinicalSynaptogenesisHGF Pathway
Dihexa is a small peptide-like compound derived from angiotensin IV analog research at Washington State University (Joseph Harding's lab). Described as a potentiator of hepatocyte growth factor (HGF) signaling via c-Met …
Full Dihexa profile →
Semax
Cognitive & Nootropic
Not Approved
CognitiveNeuroprotectionNootropicBDNF
Semax is a synthetic heptapeptide analog of the ACTH(4-10) fragment, developed in Russia in the 1980s by the Institute of Molecular Genetics. It is approved as a pharmaceutical drug in Russia for cognitive impairment, is…
Full Semax profile →
Technical Specs Comparison
MetricDihexaSemax
Research Status Preclinical / Research Extensively Studied
Molecular Weight 524.68 Da 813.9 Da
Half-Life Days to weeks (estimated; data limited) ~minutes (plasma); CNS effects 24h+
Peak Time Unknown; CNS penetration demonstrated in animal models ~30–60 min (intranasal)
Typical Dose 1-3 mg/kg (rodent); human doses not established 300–900 µg intranasal
Frequency Varies by protocol Once or twice daily
Route Oral (research); subcutaneous; intranasal (experimental) Intranasal (primary) / Subcutaneous
Amino Acids 2 7
WADA Status Not listed Not Listed
FDA Status Not approved; preclinical stage Not Approved
Stack Compatibility & Key Differences
Both are active research compounds. See individual pages for full protocol data.
PK Plotter
Visualize Semax plasma levels → Plot →
Frequently Asked Questions
What is the difference between Dihexa and Semax?
Dihexa: Dihexa is a small peptide-like compound derived from angiotensin IV analog research at Washington State University (Joseph Harding's lab). Described as a potentiator of hepatocyte growth factor (HGF) signaling via c-Met … Semax: Semax is a synthetic heptapeptide analog of the ACTH(4-10) fragment, developed in Russia in the 1980s by the Institute of Molecular Genetics. It is approved as a pharmaceutical drug in Russia for cognitive impairment, is…
Can you stack Dihexa and Semax?
Both are active research compounds. See individual pages for full protocol data.
Which has a longer half-life, Dihexa or Semax?
Dihexa half-life: Days to weeks (estimated; data limited). Semax half-life: ~minutes (plasma); CNS effects 24h+.
✓
Verified Scientific Data
All specifications on this page are sourced from peer-reviewed literature and primary research. Half-life values, dosing ranges, and mechanism data are cross-referenced against published studies. Last audited 2026-06-07.
● Peer-reviewed sources ● Audit timestamp: 2026-06-07 ● Data version: ASCEND Wiki 2026
Data sourced from ASCEND Wiki · Dihexa profile · Semax profile · All comparisons
Ready to calculate your exact draw volume?
Enter your vial size and BAC water to get precise IU markings for any dose.
Calculate Dihexa dose → Calculate Semax dose →