⚖ Head-to-Head · Peptide vs GLP-1 Fat Loss

AOD-9604 vs Semaglutide

Mechanism, half-life, dosing & research status compared side-by-side.

AOD-9604
Weight Management
GRAS / Not Approved (Drug)
Weight ManagementBody CompositionFat LossMetabolic
AOD-9604 is a synthetic peptide corresponding to the C-terminal fragment of human growth hormone (hGH residues 177-191), stabilized with a disulfide bond. It was engineered to isolate the lipolytic (fat-burning) properti…
Full AOD-9604 profile →
Semaglutide
Metabolic / GLP-1 Agonist
Approved (T2D, obesity)
GLP-1 AgonistFDA ApprovedWeight ManagementMetabolicDiabetes
Semaglutide is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist developed by Novo Nordisk. Approved for type 2 diabetes management and chronic weight management, it has become one of the most widely prescri…
Full Semaglutide profile →
Technical Specs Comparison
MetricAOD-9604Semaglutide
Research Status Extensively Studied FDA Approved
Molecular Weight 1,815.1 Da 4113.58 Da
Half-Life ~1–2 hours ~168 hours (7 days)
Peak Time ~30–60 min 1-3 days post-injection
Typical Dose 250–500 µg 0.25-2.4 mg/week (SC); 3-14 mg/day (oral)
Frequency Once daily (fasted) Once weekly (SC); once daily (oral)
Route Subcutaneous / Oral (poor bioavailability) Subcutaneous injection; oral tablet
Amino Acids 15 31
WADA Status Prohibited Not listed
FDA Status GRAS / Not Approved (Drug) Approved (T2D, obesity)
Stack Compatibility & Key Differences
Semaglutide has FDA approval; AOD-9604 is research-only.
PK Plotter · Visualize plasma levels over time
Plot AOD-9604 → Plot Semaglutide →
Frequently Asked Questions
What is the difference between AOD-9604 and Semaglutide?
AOD-9604: AOD-9604 is a synthetic peptide corresponding to the C-terminal fragment of human growth hormone (hGH residues 177-191), stabilized with a disulfide bond. It was engineered to isolate the lipolytic (fat-burning) properti… Semaglutide: Semaglutide is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist developed by Novo Nordisk. Approved for type 2 diabetes management and chronic weight management, it has become one of the most widely prescri…
Can you stack AOD-9604 and Semaglutide?
Semaglutide has FDA approval; AOD-9604 is research-only.
Which has a longer half-life, AOD-9604 or Semaglutide?
AOD-9604 half-life: ~1–2 hours. Semaglutide half-life: ~168 hours (7 days).
✓
Verified Scientific Data
All specifications on this page are sourced from peer-reviewed literature and primary research. Half-life values, dosing ranges, and mechanism data are cross-referenced against published studies. Last audited 2026-06-07.
● Peer-reviewed sources ● Audit timestamp: 2026-06-07 ● Data version: ASCEND Wiki 2026
Data sourced from ASCEND Wiki · AOD-9604 profile · Semaglutide profile · All comparisons
Ready to calculate your exact draw volume?
Enter your vial size and BAC water to get precise IU markings for any dose.
Calculate AOD-9604 dose → Calculate Semaglutide dose →