CJC-1295 + Ipamorelin: The GHRH/GHRP Stack Explained

CJC-1295 (No DAC / mod GRF 1-29) is a GHRH analog - it binds GHRH receptors in the pituitary and directly stimulates GH synthesis and release. Ipamorelin is a GHRP (ghrelin receptor agonist) - it binds ghrelin receptors independently, triggering a separate signaling cascade that also promotes GH secretion.

The synergy is not additive - it is multiplicative. A landmark study by Khorram et al. demonstrated that combined GHRH + GHRP administration produced GH pulses 5–10× larger than either compound alone at equivalent doses. This occurs because the two pathways converge on somatotroph cells via different second messengers (cAMP for GHRH, PKC/IP3 for ghrelin), amplifying the net secretory signal beyond what either receptor class can achieve independently.

Endogenous GH secretion is pulsatile - the largest pulse occurs approximately 60–90 minutes after sleep onset, driven by delta-wave sleep activation of hypothalamic GHRH neurons. Pre-sleep injection of the CJC-1295 + Ipamorelin stack amplifies this natural pulse rather than creating an off-cycle pulse at a random time of day.

CJC-1295 (No DAC) has an in vivo half-life of ~30 minutes, meaning it clears before the next natural pulse if dosed more than 2–3 hours earlier. The protocol of injecting 30–45 minutes before sleep onset is specifically designed to have peak plasma concentrations coincide with the onset of the natural nocturnal GH pulse - producing the largest measurable GH spike within the research protocol window.

CJC-1295 No DAC: 5mg vial + 2mL BAC water = 2.5mg/mL (2,500 mcg/mL). A 100 mcg dose = 0.04mL = 4 units. A 300 mcg dose = 0.12mL = 12 units. Both are readable on a U-100 syringe with a 0.3mL barrel - use a 0.3mL syringe, not a 1mL, to make 4-unit reads accurate.

Ipamorelin: 5mg vial + 2.5mL BAC water = 2mg/mL (2,000 mcg/mL). A 200 mcg dose = 0.1mL = 10 units. A 300 mcg dose = 0.15mL = 15 units. Again, clean reads on a 0.3mL barrel. The most common error is using a 1mL syringe - each graduation is 10 units on a 100-unit syringe, so a 4-unit draw for CJC-1295 becomes essentially unreadable.